Wednesday, November 28, 2007

FDA Urges Psych Warning for Flu Drugs

WASHINGTON (Nov. 23) - U.S. Food and Drug Administration staff are recommending new warnings about psychiatric events observed in patients on Roche Holding AG's Tamiflu and GlaxoSmithKline Plc's Relenza, according to documents posted on Friday.


An FDA advisory panel will discuss the recommendations for these influenza drugs at a meeting on the drugs' safety next week. The FDA held a similar meeting two years ago on Tamiflu, after reports of deaths of children in Japan linked to abnormal psychiatric behavior.

Experts two years ago were unable to find a connection between the drug and the deaths.

In documents prepared for the meeting next week and posted on the FDA Web site, FDA staff recommend that Tamiflu's label be changed to note "some cases in Japanese adult and pediatric patients resulted in a fatal outcome."

The FDA staff also reviewed Relenza, a drug in the same class as Tamiflu, recommending its label be changed to note "reports of hallucinations, delirium and abnormal behavior" observed in some patients taking the drug.

(Reporting by Kim Dixon; Editing by Gerald E. McCormick)

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2007-11-23 11:48:28

Thursday, November 8, 2007

Hot or Cold?

Another common questions that patients have is whether they should be applying heat or cold to an area of their body that is injured or irritated. Follow the clinical guidelines below but always use your judgment, if it seems to make the symptoms worse then try the opposite therapy.

When to use ice:

Ice is best used for acute (new) injuries that are less than 72 hours old. Ice can also be applied after exercise, physical therapy, chiropractic manipulation and general work around the house.

Using the RICE (rest, ice, compression, elevation) principles is a good rule of thumb to follow. Generally you should ice an area of your body for 5-20 minutes. Limbs should be iced for not more than 10 minutes. Ice should never be directly applied to the skin, you should have a thin garment or layer of clothing.

Icing too long can create what's called a Hunter's response. This occurs when the body think the area is freezing and actually sends more blood flow. Another concern is icing directly on the skin can cause ice burns, so never sleep with an ice-pack on.


When to use heat:

Moist heat is best applied to an area of the body that requires increase blood flow. It is generally wise to apply heat to an injured area after 72 hours. Heat can also be used to loosen up stiff joints and tight muscles and works well when applied before any rehab or exercise.

Studies have shown that applying heat to muscles prior to exercise greatly reduces muscle related injuries. A good place to apply these principles is in the shower.

Warm baths can be beneficial to the injured area, but use caution. Since heat increases blood flow to an area it can also create mild to moderate inflammation.

These are general guidelines, you should always follow the recommendations from your doctor or therapist


Stay healthy!

Red Flags...What you should be telling your doctors

Today's post results from several conversations this week with patients. I find it more and more that doctors are not asking their patients crucial questions regarding their patient's health. Red flags are important history clues to rule out when they are present.

Here is a list of symptoms that you should make your physician very aware of:

- night sweats
- loss of appetite or taste for food
- unexplained weight loss
- pain at night or rest
- swelling in the arms or legs
- pitting edema (squishy)
- numbness or tingling in the hands or feet
- poor wound or bruise healing
- blood in your stool (bright red or black)
- blood in your vomit


The above listed symptoms can be early signs of many disease processes. Be sure to have your doctor address some of these concerns.